The Indianapolis Colts are seeking their first victory in 10 tries this season, but they'll have to do it without Joseph Addai.
Addai had been active the previous two weeks, but he didn't have a carry in either game. He has rushed the ball just twice over the past four weeks because of the injury.
On the Jaguars' side, the team will be without the services of Terrance Knighton for the first time since 2008.
The defensive tackle is inactive for Sunday's game with an ankle injury. It's the first missed game of his career, snapping a streak of 40 consecutive starts.
The Associated Press contributed to this report.