Mack suffered a fractured right hand in Sunday's 33-13 win over the Jacksonville Jaguars. Coach Frank Reich said Monday that the running back underwent surgery today and will miss this week, at least. There is no timetable for a return, but it will likely be a few games.
NFL Network Insider Ian Rapoport added that Mack broke a metacarpal in his right hand, a common fracture, per a source. The RB can play with a splint on his hand when he returns.
Mack fractured the hand early in the third quarter, which brought an abrupt end to what had been a fantastic first half-plus. On the day, the running back repeatedly dashed through the Jags defense, providing highlight plays en route to 109 rushing yards on 14 carries and a TD.
With Mack out, Indy leaned on Jonathan Williams, who authored a superb day, gobbling up 116 yards on 13 totes, including a 48-yard scamper as the Colts galloped all over the Jags D.
Williams and Jordan Wilkins, who missed Sunday's tilt with an ankle injury, will take the early-down role as long as Mack is out, with Nyheim Hines likely to remain in his role as change-of-pace back.
Here are other injuries we are monitoring Monday:
» Kansas City Chiefs RB Damien Williams (rib) and S Jordan Lucas (shoulder) have been ruled out for the remainder of "Monday Night Football." Chiefs RB LeSean McCoy is being evaluated for a concussion.
The Chiefs announced the following inactives for "MNF": DE Alex Okafor, TE Blake Bell, OL Nick Allegretti, OL Jackson Barton, RB Darwin Thompson, QB Chad Henne and CB Kendall Fuller.
The Los Angeles Chargers announced the following inactives for "MNF": OL Sam Tevi, OL Russell Okung, WR Geremy Davis, RB Justin Jackson, LB Drue Tranquill, DT T.Y. McGill Jr. and QB Easton Stick.
»Detroit Lions coach Matt Patricia said the status of quarterback Matthew Stafford (back) has not changed. After missing the past two games, he remains "week to week."
»Tampa Bay Buccaneers coach Bruce Arians said Monday that Jameis Winston's ankle, which he rolled late in Sunday's loss to the Saints, appears fine and he expects the QB to play in Week 12 against the Atlanta Falcons.
»San Francisco 49ers coach Kyle Shanahan provided an update on the hamstring strain defensive end Dee Ford suffered against the Cardinals, saying that his type of injury brings a concern that a player could miss a couple weeks. He's still be evaluated.
»Los Angeles Rams receiver Brandin Cooks is expected to play next week against the Ravens, coach Sean McVay told reporters. Cooks has missed the last two games with a concussion.
»Seattle Seahawks coach Pete Carroll said he is optimistic about having receiver Tyler Lockett (leg contusion) against the Eagles, but he has to show progress in practice through the week. Carroll also said tight end Luke Willson (hamstring) is unlikely to play, which could lead to Ed Dickson being activated off IR.
»Philadelphia Eagles right tackle Lane Johnson is in concussion protocol after exiting Sunday's loss to the New England Patriots in the first half, according to Doug Pederson. The coach added that rookie first-round pick Andre Dillard could get reps at right tackle in practice this week.
»New York Giants tight end Evan Engram is out of his walking boot, per NFL Network's Kimberly Jones, and hopes to ramp up his workload this week. Engram missed the Giants' pre-bye tilt against the Jets. He had a 2-4 week recovery timeframe.
»New York Jets coach Adam Gase said Monday that left tackle Kelvin Beachum aggravated his ankle injury, but it is not considered as severe as before. Rookie tackle Chuma Edoga (ankle/knee) is day-to-day but the Jets are optimistic he can play this week.
»Pittsburgh Steelers running back James Conner's AC joint injury isn't worse than it has previously been after he exited last week's game against the Browns, NFL Network's Tom Pelissero reports. Conner's status for Sunday's is still up in the air for Sunday's game.
»The Denver Broncos haven't ruled out activating rookie quarterback Drew Lock this week to be the backup, but it's not likely, NFL Network's James Palmer notes. Lock will get scout team reps this week along with some other reps with the offense, which is similar to last week.
»Houston Texans offensive lineman Seantrel Henderson has been released off the non-football injury list, Rapoport reported, per a source informed. He was dealing with a slight back injury, but he's healthy now, Rapoport added.
The Texans did not practice either. Wide receiver Will Fuller (hamstring) was listed as limited, while quarterback Deshaun Watson (ankle) appeared on the injury report but as a full participant.
»Cincinnati Bengals coach Zac Taylor said wide receiver Auden Tate suffered a cervical strain and is in the concussion protocol after taking a hard hit during Cincinnati's loss to the Raiders on Sunday.
»Kansas City Chiefs defensive end Emmanuel Ogbah (pectoral) was placed on injured reserve. In a corresponding move, wide receiver Gehrig Dieter has been promoted from the practice squad to the active roster.
»The Oakland Raiders signed veteran linebacker Preston Brown, who was released by the Bengals last week. He recorded 52 tackles in nine games with Cincinnati. In a corresponding move, Oakland placed wide receiver Dwayne Harris on injured reserve.
»Indianapolis Colts tight end Eric Ebron (ankle), wide receiver T.Y. Hilton (calf), running back Marlon Mack (hand), and cornerback Rock Ya-Sin (ankle) were listed as limited participants in an estimated injury report. Indianapolis, which plays Houston on Thursday, is not practicing Monday.
»Dallas Cowboys cornerback Anthony Brown will undergo season-ending surgery on his injured tricep, coach Jason Garrett said Monday.