Trying to make something out of nothing, Jackson reversed field, lost ground and ultimately fumbled deep in his own territory.
Although Jackson atoned with a 28-yard touchdown reception a minute later, he still owned up to the egregious error on special teams.
"It was a roller coaster, man. Just one of those games," Jackson said. "We just fell on the short end of the stick this time. Personally, I'm very frustrated. I know I need to protect the ball and it got away from me. That's on me.
"It was just one of those things where I was just trying to make a play for my team ... I just got to take that on the chin, you know, the fumble, I know better than that."
Coach Jay Gruden had no second thoughts about replacing primary punt returner Jamison Crowder with Jackson in a game that was tied at nine deep in the fourth quarter.
"DeSean has a history of making big plays in key situations," Gruden explained, "and I don't regret that decision one bit."