The Packers will attempt to hand the Cardinals their first loss of 2021 without their top weapon.
Adams spent the week on the reserve/COVID-19 list and did not travel with the team, but a slim chance remained of him clearing the protocol in time to travel on his own to Glendale before kickoff.
That did not happen, officially resigning Adams to watch his teammates from home.
Adams and Aaron Rodgers have teamed up to record the third-most receiving yards between a quarterback and receiver pairing this season (744), hooking up for three touchdowns along the way. Rodgers hasn't been bashful about his preference to target Adams, throwing in his direction 73 times this season.
With Adams' involvement, Green Bay ranks 18th in passing yards per game. No other Packers pass catcher has broken even 200 receiving yards through seven weeks, meaning Adams' absence will remove a massive chunk of production from Green Bay's passing attack.
With Allen Lazard also out due to being placed on the reserve/COVID-19 list, the Packers will hope Randall Cobb, Robert Tonyan, Juwann Winfree -- whom Green Bay is elevating to the active roster, per NFL Network's Mike Garafolo -- and others will be able to pick up the slack against a Cardinals team that ranks seventh in the NFL in total yards per game.