The New Orleans Saints will be without their most vaunted offensive weapon for a fourth game in a row.
Starting tackles Terron Armstead (knee) and Ryan Ramczyk (knee) will also not be able to go. As a potential replacement, New Orleans is signing offensive lineman Caleb Benenoch off their practice squad to the 53-man roster ahead of Thursday's game, NFL Network's Tom Pelissero reported.
Kamara was questionable coming into Thursday due to the knee injury that's kept him sidelined the past three games. His absence will be elongated as the Saints aim to snap their four-game losing streak without him.
Kamara, who was limited in practice this week, has run for 530 yards and three touchdowns in eight games with 32 catches for 310 yards and four touchdowns, as well.
Armstead did not practice all week, while Ramczyk sat out Tuesday and Wednesday.