Mebane, a defensive tackle from California, was taken with the 85th pick. The 6-foot-1, 314-pound Mebane is expected to join Seattle's rotation on running downs. The Seahawks' defensive front was depleted by injuries last season.
Mebane earned first-team all-Pac-10 honors as a junior and senior at Cal. He started 31 of his 41 career games.
The Seahawks did not have a first-round selection after trading that choice to New England for wide receiver Deion Branch.