Orakpo announced Monday he is retiring after playing 10 seasons in the NFL, a career span that saw him play for two teams.
"This is definitely a decision solely made for just walking away from the game health-wise," Orakpo said. "I think I played enough football. As you get older, the perception is we can keep going and going and going. But your body starts talking to you and this is the first time I actually sat down and listened."
The 32-year-old Orakpo entered the league in 2009 out of Texas as a first-round pick with the Washington Redskins, where he spent six seasons and made three Pro Bowls.
He finishes his career appearing in 132 games and totaling 425 tackles, 66 sacks and 125 quarterback hits.
"On behalf of my family and the organization, I want to congratulate Brian on a fantastic NFL career," Titans controlling owner Amy Adams Strunk said in a statement. "His leadership and production were important to our turnaround on the field. I also know his influence on our team will be felt for many years to come. We want to wish him the best in his life after football, and he should know that he will always have a home with the Titans."