The biggest, best reactions from Week 1

Actor Sterling K. Brown narrates 2022 NFL Kickoff game opening.

Here's everything you need to know when the Denver Broncos play the Seattle Seahawks in Week 1 of the 2022 season.

Here's everything you need to know when the San Francisco 49ers play the Chicago Bears in Week 1 of the 2022 season.

Here's everything you need to know when the New England Patriots play the Miami Dolphins in Week 1 of the 2022 season.

Here's everything you need to know when the Cleveland Browns play the Carolina Panthers in Week 1 of the 2022 season.

Here's everything you need to know when the Indianapolis Colts play the Houston Texans in Week 1 of the 2022 season.

Here's everything you need to know when the Philadelphia Eagles play the Detroit Lions in Week 1 of the 2022 season.

Here's everything you need to know when the Tampa Bay Buccaneers play the Dallas Cowboys in Week 1 of the 2022 season.

Here's everything you need to know when the Green Bay Packers play the Minnesota Vikings in Week 1 of the 2022 season.

Here's everything you need to know when the New York Giants play the Tennessee Titans in Week 1 of the 2022 season.

Here's everything you need to know when the Jacksonville Jaguars play the Washington Commanders in Week 1 of the 2022 season.

Here's everything you need to know when the Baltimore Ravens play the New York Jets in Week 1 of the 2022 season.

Here's everything you need to know when the Pittsburgh Steelers play the Cincinnati Bengals in Week 1 of the 2022 season.

Here's everything you need to know when the Kansas City Chiefs play the Arizona Cardinals in Week 1 of the 2022 season.

No one takes Kickoff 2022 more seriously than Commissioner Roger Goodell.

Watch the best plays from every NFL Kickoff Game since 2004!

Colombian singer J Balvin has taken the music and fashion industries by storm, elevating the Latino community across the world. The reggaeton superstar will headline this NFL season's kickoff concert, prior to Bills versus Rams matchup. The Grammy-nominated sensation sits down with NFL Network's MJ Acosta-Ruiz to chat about the importance of the Latino representation in the NFL, his music collabs, a new sneaker deal, and mental health.

Former Arizona Cardinals wide receiver Larry Fitzgerald speaks with NFL Network's Colleen Wolfe about some of the marquee Week 1 games in the 2022 NFL season as part of the 'NFL Kickoff 2022' show.

Los Angeles Rams quarterback Matthew Stafford joins "NFL Kickoff 2022" on NFL Network with Colleen Wolfe and David Carr to preview the Rams' season opener vs. the Buffalo Bills.

NFL Network's Kayla Burton reports that Los Angeles Rams cornerback Jalen Ramsey is refusing to praise the Buffalo Bills ahead of the Rams' season-opening matchup in primetime of Week 1 of the 2022 NFL regular season.

NFL Network's Tom Pelissero says there is a 'good' chance Atlanta Falcons rookie Drake London will play in Week 1 of the 2022 NFL regular season against the New Orleans Saints.

NFL Network's Mike Garafolo discusses Pittsburgh Steelers wide receiver Diontae Johnson's injury status entering Week 1 vs. Cincinnati Bengals.

Pittsburgh Steelers head coach Mike Tomlin names quarterback Mitch Trubisky QB1 Week 1 vs. Bengals.

NFL Network's Scott Pioli and the "GMFB" crew discuss top storylines and Week 1 matchups.

Here's everything you need to know when the Buffalo Bills play the Los Angeles Rams in Week 1 of the 2022 season.