Can't-Miss Play: 74-yard TD! Dee Winters delivers pick-six score vs. Rivers on 'MNF'

San Francisco 49ers linebacker Dee Winters ices Indianapolis Colts with huge 74-yard pick-six against quarterback Philip Rivers.

Indianapolis Colts quarterback Philip Rivers arcs a perfect 20-yard touchdown pass to wide receiver Alec Pierce to open the scoring on "Monday Night Football" against the San Francisco 49ers.

New England Patriots linebacker K'Lavon Chaisson lays a huge hit on Baltimore Ravens wide receiver Zay Flowers for a fumble with the clock ticking in the fourth quarter.

New England Patriots quarterback Drake Maye uncorks a 37-yard touchdown pass to wide receiver Kyle Williams.

New England Patriots wide receiver Stefon Diggs makes a spectacular snag on 25-yard strike from quarterback Drake Maye.

Pittsburgh Steelers running back Jaylen Warren breaks free for a second 45-yard touchdown run against the Detroit Lions defense.

Las Vegas Raiders running back Ashton Jeanty scores his second touchdown of the game against the Houston Texans on a play starting from their own territory, adding a 51-yard scoring run to his 60-yard touchdown catch earlier in the contest.

Pittsburgh Steelers running back Jaylen Warren takes a toss sweep left and cuts back into an open lane to the end zone for a 45-yard touchdown run to put the Steelers up 21-10 against the Detroit Lions.

Denver Broncos quarterback Bo Nix connects with wide receiver Troy Franklin for a massive 48-yard gain.

Jacksonville Jaguars wide receiver Parker Washington catches a pass from Trevor Lawrence and breaks a Denver Broncos' ankles for huge 63-yard gain.

Las Vegas Raiders running back Ashton Jeanty hauls in a pass from quarterback Geno Smith and turns it into a house call for a 60-yard touchdown against the Houston Texans.

Denver Broncos running back RJ Harvey bulldozes a Jacksonville Jaguar that leads to a huge 38-yard breakaway for a touchdown.

Pittsburgh Steelers running back Kenneth Gainwell somehow makes a deep-ball reception while lying on the ground, gets himself up and sprints into the end zone for a miraculous touchdown headed into halftime against the Detroit Lions.

Jacksonville Jaguars quarterback Trevor Lawrence floats a perfect 12-yard pass to wide receiver Parker Washington for a touchdown.

Houston Texans cornerback Derek Stingley Jr. opens the scoring against the Las Vegas Raiders in Week 16, intercepting a pass by quarterback Geno Smith and returning the ball 31 yards for a touchdown.

Arizona Cardinals quarterback Jacoby Brissett launches deep pass to wide receiver Michael Wilson who somehow hauls in an unbelievable 32-yard touchdown against the Atlanta Falcons.

New Orleans Saints tight end Taysom Hill dials launch codes to wide receiver Chris Olave for 39-yard TD strike

Cincinnati Bengals wide receiver Ja'Marr Chase works back to the football on a 36-yard reception through multiple Miami Dolphins defenders.

Carolina Panthers quarterback Bryce Young throws a 6-yard touchdown pass to tight end Ja'Tevion Sanders.

Tennessee Titans wide receiver Chimere Dike makes a 30-yard sideline grab from quarterback Cam Ward against the Kansas City Chiefs.

Los Angeles Chargers quarterback Justin Herbert steps up in the pocket and launches a 50-yard pass to wide receiver Quentin Johnston who skies over a Dallas Cowboys defender along the sideline.

Dallas Cowboys quarterback Dak Prescott unleashes a 38-yard touchdown pass to wide receiver George Pickens to regain the lead against the Los Angeles Chargers.

Minnesota Vikings quarterback J.J. McCarthy's pass goes off the hands of wide receiver Jalen Nailor and is intercepted by New York Giants cornerback Paulson Adebo on a toe-tapping grab.

Miami Dolphins running back De'Von Achane turns upfield on a 48-yard touchdown burst against the Cincinnati Bengals on a toss play.

Cincinnati Bengals wide receiver Tee Higgins catches a 9-yard touchdown dime in the corner of the end zone from quarterback Joe Burrow against the Miami Dolphins.