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2025 NFL schedule, NFC West: Takeaways, full list of games for 49ers, Cardinals, Rams, Seahawks

The 2025 NFL schedule has been revealed, setting the calendar from fall into winter for all 32 franchises. So, how does every team's 17-game lineup fit into the 18-week slate? What are the biggest takeaways from each draw? NFL.com analysts provide the initial intel you need to know.

Navigate to your team by clicking the divisions below:

Arizona Cardinals
SOS: .457 · Rank: T-27

Cardinals' 2025 schedule


Week 1: at Saints

Week 2: Panthers

Week 3: at 49ers

Week 4: Seahawks (TNF)

Week 5: Titans

Week 6: at Colts

Week 7: Packers

Week 8: BYE

Week 9: at Cowboys (MNF)

Week 10: at Seahawks

Week 11: 49ers

Week 12: Jaguars

Week 13: at Buccaneers

Week 14: Rams

Week 15: at Texans

Week 16: Falcons

Week 17: at Bengals (TBD)

Week 18: at Rams (TBD)


Three biggest takeaways


  1. Investments to show immediate return? The Cardinals’ revamped defense -- particularly the unit’s beefed up front seven -- could have the ultimate treat waiting for it when the team arrives in New Orleans to kickoff the campaign: an untested rookie quarterback. In fact, the Saints will be the first of potentially four opponents Arizona will face through Week 6 that could feature a new face under center. If the Cards’ upgraded pass rush can rattle Sam Darnold, clamp down on Cam Ward and disrupt whoever wins the Colts’ QB competition, Jonathan Gannon’s group could be poised for a fast start in what should be a hotly contested division.
  2. Stack wins early or else. However, If the Cardinals can’t take advantage of their more forgiving fall slate, they could be in for a very long season. The back-half of their schedule is brutal. Unlike the 49ers, who enjoy plenty of time at home after the midseason mark, the Cards will hit the road six times after their Week 8 bye, with five of those trips involving teams that won nine or more games a year ago. The lone outlier: the Cowboys, who finished 7-10 despite not having Dak Prescott for most of the year.
  3. Schedule slight? Kyler Murray’s Dallas homecoming in Week 9 is the second (and last) prime-time game currently on the Cards’ calendar (Week 17 and 18 are still TBD). The Seahawks and Rams, meanwhile, both have four, while the 49ers have five. Will Kyler & Co. play their way into a Saturday night showcase down the stretch?


NFL Research note


The Cardinals are tied for the fourth-lowest road win percentage in the NFL (.235) since the start of the 2023 season (excluding international games), with just two total away wins after Week 9 during that period.


Cardinals' offseason: Additions | Draft picks | Undrafted rookies | Departures

Los Angeles Rams
SOS: .491 · Rank: 17

Rams' 2025 schedule


Week 1: Texans

Week 2: at Titans

Week 3: at Eagles

Week 4: Colts

Week 5: 49ers (TNF)

Week 6: at Ravens

Week 7: at Jaguars (London)

Week 8: BYE

Week 9: Saints

Week 10: at 49ers

Week 11: Seahawks

Week 12: Buccaneers (SNF)

Week 13: at Panthers

Week 14: at Cardinals

Week 15: Lions

Week 16: at Seahawks (TNF)

Week 17: at Falcons (MNF)

Week 18: Cardinals (TBD)


Three biggest takeaways


  1. Fuel the jets. The Rams have an interesting (and potentially taxing) wrinkle in their fall schedule, with all four of their games against the AFC South -- including a trip to Tennessee and a date with the Jags at Wembley -- occurring before their Week 8 bye. Sprinkled in between those interconference contests are three juicy matchups: a Thursday night showdown with San Francisco and circle-your-calendar affairs at Philadelphia and at Baltimore. (Yep, that’s a lot of travel for Sean McVay’s crew to begin the season.) Although the Rams’ head man has won three straight against the Niners, he’s just 8-15 lifetime (including playoffs) against John Harbaugh, Kyle Shanahan and Nick Sirianni. He’s actually never beaten Sirianni head-to-head, sporting an 0-3 record against the reigning Super Bowl-winning coach. ... So perhaps we won’t be the only ones who have Week 3 highlighted. 
  2. Opportunities await beyond the break. The NFC West competition doesn’t really get going for the Rams until the second-half of the season, with five of their six division games coming after Week 9 -- including both legs against Seattle. As if these two intra-division games weren't tough enough, the timing of these two meetings with the ‘Hawks that could really pose a problem: Game 1 (home) immediately follows a trip to San Francisco, while Game 2 (at Seattle) hits just four days after L.A. hosts Detroit. Not ideal. Still, even if McVay’s squad gets off to another slow start, and winds up on the wrong side of those early-season monster matchups, they'll still have prime opportunities to re-enter the race when November arrives. 
  3. A rising rivalry returns. Over the last two seasons, the Lions and Rams rank first and second, respectively, in regular-season wins from Week 10 on. So it shouldn’t come as a surprise that the next iteration of the Gofford Bowl will take place firmly during the campaign’s final quarter -- in the choice afternoon time slot with the G.O.A.T. on the call. 


NFL Research note


The Rams have the NFL's fourth-highest win percentage in December (.703) since Sean McVay became the team's head coach in 2017. L.A. has been been particularly good on the road during the holiday month, winning at a 68.4% clip -- second-best behind Kansas City (75%).


Rams' offseason: Additions | Draft picks | Undrafted rookies | Departures

San Francisco 49ers
SOS: .415 · Rank: 32

49ers' 2025 schedule


Week 1: at Seahawks

Week 2: at Saints

Week 3: Cardinals

Week 4: Jaguars

Week 5: at Rams (TNF)

Week 6: at Buccaneers

Week 7: Falcons (SNF)

Week 8: at Texans

Week 9: at Giants

Week 10: Rams

Week 11: at Cardinals

Week 12: Panthers (MNF)

Week 13: at Browns

Week 14: BYE

Week 15: Titans

Week 16: at Colts (MNF)

Week 17: Bears (SNF)

Week 18: Seahawks (TBD)


Three biggest takeaways


  1. Have schedule, will travel. The 49ers will hit the road running in 2025, serving as the visiting side six times over the first nine weeks of the campaign. A potentially tough ask for a team that's been notorious for starting slow and is coming off its first sub.-500 road mark (2-6) since dropping all eight away games in 2018. The 49ers have never played more than five road contests through Week 9 in the Kyle Shanahan era. 
  2. Beware of Spooky Season. San Francisco’s front-loaded schedule also features the team’s toughest stretch of the year -- a four-game sequence beginning in Week 5 that spans all of October and includes matchups with three 2024 playoff teams (and one near miss). The Niners begin the month with a division tilt at SoFi (on Thursday night), follow that up with a cross-country trip to Tampa, then fly back to the West Coast to host the rising Falcons (on Sunday night), before a pre-Halloween haunt in Houston. That’s a lot of offensive firepower on tap for Robert Saleh and his new-look defense. 
  3. Path back to the Super Bowl? After all of their early-season travel, things brighten up quite a bit by the Bay in the second half. The 49ers have one of the more favorable slates following the midpoint, with seven of their final nine opponents sub.-500 teams from a year ago (hence the 49ers’ 32nd-ranked strength of schedule). At least two of those squads (Browns, Titans), and possibly four (Giants, Seahawks), could be starting rookie QBs against Saleh’s defense. Plus, after their Week 9 trip to the Meadowlands, the Niners will play only one more game that's both outdoors and away from Levi's: at Cleveland on Nov. 30. Could we be in store for another one of Shanahan's patented second-half runs?


NFL Research note


Another scheduling quirk that could work in the 49ers' favor: They don't play a single 2024 playoff team over the final eight weeks of the season.


49ers' offseason: Additions | Draft picks | Undrafted rookies | Departures

Seattle Seahawks
SOS: .474 · Rank: T-21

Seahawks' 2025 schedule


Week 1: 49ers

Week 2: at Steelers

Week 3: Saints

Week 4: at Cardinals (TNF)

Week 5: Buccaneers

Week 6: at Jaguars

Week 7: Texans (MNF)

Week 8: BYE

Week 9: at Commanders (SNF)

Week 10: Cardinals

Week 11: at Rams

Week 12: at Titans

Week 13: Vikings

Week 14: at Falcons

Week 15: Colts

Week 16: Rams (TNF)

Week 17: at Panthers (TBD)

Week 18: at 49ers (TBD)


Three biggest takeaways


  1. Early gut-check for Seattle’s new era. Few teams initiated a bigger offseason makeover than the Seahawks, and their new foundation will be tested from the jump by the 49ers and Steelers -- two teams with extra motivation to bring it against Mike Macdonald’s club. Seattle’s last-minute win at San Francisco in Week 11 sent the Niners’ 2024 season spiraling, dissolving any hope their division rival still held of a late-season turnaround (they finished 1–7). The Steelers, as a team, might not have as much ill-will toward Seattle as Kyle Shanahan’s club, but you know DK Metcalf will want to show out against his old teammates in his new town. Let’s hope for his sake, and our viewing pleasure, a four-time league MVP is throwing him the ball in this one. 
  2. New 'Hawks will have to wait for revenge. Cooper Kupp’s return to L.A. and Sam Darnold’s meet-up with Minnesota won’t hit our screens until after midseason, but both of those reunions should be meaningful for the players involved and the Seahawks’ place in the NFC standings. 
  3. West Coast > East Coast? Seattle will play five games in the Eastern time zone during the 2025 season -- a total they’ve matched just four times this millennium. And while all of that travel and all of those hours lost might seem wholly unfair to the 12s out there, consider this: Since 2010, your Seahawks are 30-15 when playing in EST. 


NFL Research note


The Seahawks have consistently been one of the hottest teams out of the gate, owning the league's fifth-highest win percentage in September (.602) since 2000.


Seahawks' offseason: Additions | Draft picks | Undrafted rookies | Departures

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