The Eagles RB room could be back to full strength ahead of Saturday's playoff clash with the Buccaneers. Plus, other news from around the NFL.

The Seahawks will have to conclude the season without their defensive leader. Plus, more news from around the NFL.

With a playoff berth in their sights, the Eagles might have to battle the final two weeks without their top running back. Miles Sanders suffered a broken bone in his hand during Sunday's win and will undergo an MRI.

Maurice Jones-Drew identifies running backs' three biggest enemies this season, including a pair of game-wrecking defenders and one stout defensive unit. Plus, updated RB rankings.

Maurice Jones-Drew selects three RB2s who will have a bigger impact over the final month of the season than the RB1s on their respective teams. Plus, James Conner hits the top five in MJD's running back rankings. 

Can the Bills hope to compete with Josh Allen as their best rusher? Maurice Jones-Drew spotlights four teams who will be looking for a new primary RB in 2022. Plus, updated RB rankings.

NFL.com is monitoring all injury news from Sunday's games in Week 13 of the 2021 NFL season.

Michael F. Florio breaks down the top fantasy football matchups for Week 13 of the 2021 NFL season.

The Cardinals could welcome two of their top players back in time for a Week 13 contest against the Bears. Plus, other news from around the NFL on Wednesday.

Michael F. Florio breaks down which players you should target on the waiver wire ahead of Week 13 of the 2021 NFL Fantasy Football season.

Michael F. Florio breaks down the top fantasy football matchups for Week 12 of the 2021 NFL season.

All the answers you're looking for about your lineup questions. Check out the latest in the Start 'Em, Sit 'Em 2021 NFL Fantasy football league.

Michael F. Florio breaks down the top fantasy football matchups for Week 11 of the 2021 NFL season.

The Eagles activated the 21-day practice window for running back Miles Sanders. Sanders remains on IR after suffering an ankle injury in Week 7. Opening the practice window would allow Sanders to return this week if healthy.

Michael F. Florio breaks down which players you should target on the waiver wire ahead of Week 9 of the 2021 NFL Fantasy Football season.

Philadelphia running back Miles Sanders will be out at least three games. Sanders was placed on injured reserve Friday due to an ankle injury.

Michael F. Florio breaks down which players you should target on the waiver wire ahead of Week 8 of the 2021 NFL Fantasy Football season.

Will Jameis Winston take full advantage of Seattle's ghastly defense? Do the Eagles finally find their run game? Can the Bengals stop Lamar Jackson? NFL Network analysts make bold predictions for Week 7 of the 2021 NFL season.

Eagles offensive coordinator Shane Steichen explains why and how the team will get the ball in the hands of RB Miles Sanders, who has just 270 rushing yards through five games. 

NFL.com's Michael F. Florio breaks down the best and toughest fantasy matchups for Week 5 of the 2021 NFL season.

Michael F. Florio breaks down which players you should target on the waiver wire ahead of Week 4 of the 2021 NFL season.

NFL.com's Michael F. Florio's breaks down the best and toughest fantasy football matchups in Week 4 of the 2021 NFL season.

Philadelphia's loss to Dallas on Monday night exposed a number of issues for the Eagles' offense, and none was greater than its disproportionate reliance on passing. Jalen Hurts knows Miles Sanders and the run game needs more love.

Michael F. Florio breaks down which players you should target on the waiver wire ahead of Week 3 of the 2021 NFL season.

Michael F. Florio breaks down the best and worst fantasy matchups for Week 2 of the 2021 NFL season.

NFL Network Insider Ian Rapoport reports Philadelphia Eagles running back Miles Sanders breaks bone in hand.

NFL Network's Cynthia Frelund makes Week 16 player projections.

Philadelphia Eagles running back Miles Sanders discusses his career-high 131 rushing yards performance in Week 15 against Washington.

Watch the best plays by Philadelphia Eagles running back Miles Sanders in 146-yard game from Week 15 of the 2021 season.

Philadelphia Eagles running back Miles Sanders becomes first Eagles RB with two-straight 100-yard games since LeSean McCoy.

Philadelphia Eagles running back Miles Sanders revs up his engine for 37-yard explosion.

Watch Philadelphia Eagles running back Miles Sanders' best plays from his 142-yard game against the New York Jets from Week 13 of the 2021 NFL Season.

Philadelphia Eagles running back Miles Sanders shows both burst and tenacity on a 34-yard run.

Philadelphia Eagles running back Miles Sanders bursts through a hole for 27 yards.

Miles Sanders shows his patience with a 25-yard scamper.

NFL Network Insider Ian Rapoport gives an injury update on Philadelphia Eagles running back Miles Sanders.

Philadelphia Eagles running back Miles Sanders slices through Tampa Bay Buccaneers' defense with a slippery 23-yard run.

Philadelphia Eagles' O-line paves way for running back Miles Sanders' 14-yard pickup.

Former NFL RB Brian Westbrook joins "Good Morning Football" to weigh in on the Philadelphia Eagles in 2021.

NFL Network's Michael F. Florio highlights five players who are no longer "must starts" in fantasy football.

The NFL's highly anticipated series, NFL Next Generations, returns for a second season as current NFL Players pay it forward and pair up with Youth Football stars, who get the opportunity to break down plays with a Pro. This week features two players from the City of Brotherly Love as the Eagles star running back Miles Sanders is joined by the 215 Falcons Nation Champion quarterback King Salley on the latest installment of "NFL Next Generations".

For more information and to watch the entire "Next Generations" series, visit NFL.com/PlayFootball.

Philadelphia Eagles running back Miles Sanders breaks loose for an explosive 24-yard burst.

Philadelphia Eagles running back Miles Sanders navigates through traffic for a shifty 25-yard gain.

Philadelphia Eagles running back Miles Sanders bounces outside for a speedy 23-yard burst.

Philadelphia Eagles running back Miles Sanders slices through the Atlanta Falcons' front for a two-point run.

NFL Network's Adam Rank highlights five players who deserve more fantasy hype entering Week 1.

The "Good Morning Football" crew highlights RBs who will lead the NFC East in rushing yards this season.

'NFL Fantasy Live' crew shares the players they are avoiding in 2021 drafts.

NFL Network's Cynthia Frelund highlights undervalued and overvalued players in fantasy football entering 2021.

NFL Network's Kyle Brandt breaks down five running backs who need to answer the bell in 2021.