Here are the injuries and news we're monitoring around the league on this Week 6 Sunday.

Arizona will have to lean on James Conner out of the backfield for at least the next three weeks. Cardinals running back Chase Edmonds suffered a high-ankle sprain and is likely to land on injured reserve.

Panthers center Matt Paradis was carted into the locker room in the first quarter with a knee injury and will not return against New England. Plus, other news from around the NFL on Sunday.

Which roster looks best in the NFL's toughest division? Is the Rams' top-heavy blueprint built for success? Can the 49ers return to the Super Bowl with a rookie at quarterback? Gregg Rosenthal projects the starters for every team in the NFC West.

The deadline for NFL teams to option the fifth year on rookie contracts for their 2018 first-round picks is Monday, May 3, and some clubs are getting out ahead of the pack.

Gil Brandt examines which first-round picks from 2018 should have their fifth-year options picked up. Where do the Browns' Baker Mayfield and the Jets' Sam Darnold stand?

Chris Wesseling assesses the landscape of NFL offenses now that the draft has concluded and the majority of free-agent signings are in the books. Which units are the most potent? Here are the top 10 attacks heading into the 2020 season.

Smack dab in the middle of offseason roster reconstruction, the spotlight's on NFL decision makers. Perfect time for Gregg Rosenthal to provide his annual GM Power Rankings! And at the moment, no general manager's flying higher than Kansas City's Brett Veach.

Despite the 10-year age gap, San Francisco 49ers offensive linemen Mike McGlinchey and Joe Staley have formed a close bond that is indicative of the organization's tight-knit culture.

Kyle Shanahan has always used pre-snap motion in his offense, but the 49ers now utilize shifts or motion on 79 percent of their offensive plays. Nick Shook explores the effectiveness.

Kirk Cousins and the Minnesota Vikings travel to Santa Clara to take on Jimmy Garoppolo and the San Francisco 49ers on Saturday. Jeremy Bergman previews the Divisional Round playoff game.

The San Francisco 49ers outlasted the New Orleans Saints in an instant classic that gives the Niners a clear path toward the NFC's No. 1 seed. But the win had an even deeper, personal meaning for the franchise, Jim Trotter writes.

With the Cowboys losing to the Bears on Thursday night, the Eagles inched closer to the postseason. Charley Casserly examines Philly's playoff path and four other storylines to watch in Week 14.

The Seattle Seahawks (8-2) escaped Levi's Stadium with a nail-biting 27-24 overtime victory over the previously undefeated San Francisco 49ers (8-1) on the legs of Jason Myers.

Jelani Scott previews what to watch for as the Seattle Seahawks and San Francisco 49ers clash in an NFC West bout on "Monday Night Football."

Odell Beckham Jr. has been a non-factor for the Browns' offense. Brian Baldinger explains how Cleveland should utilize its star receiver and what two other teams can do to improve in Week 10.

The San Francisco 49ers look to welcome back LT Joe Staley and FB Kyle Juszczyk on Monday night as they look to widen their lead in the NFC West and remain the only undefeated team in the NFL.

Neil Reynolds from Sky Sports recaps Week 8 of the 2019 NFL season

Week 8 is here! Check out the full tally of the official injury report and gameday designations for all 13 Sunday games.

Arizona Cardinals running back David Johnson (ankle) is expected to play against the New York Giants, sources tell Ian Rapoport. Plus other injuries we're monitoring ahead of the Week 7 games.

Week 7 is here! Check out the full tally of the official injury report and gameday designations for all 12 Sunday games.

Sunday had plenty of notable winners, but Adam Schein says the day was more defined by a series of jarring defeats. Here are the nine most significant losses in a head-scratching Week 6.

The 49ers went into the L.A. Coliseum and held Jared Goff and the Rams to just 157 total yards in a 20-7 victory. Michael Silver examines how San Francisco did it and what it means for the rest of the NFC.

Week 6 is here! Check out the full tally of the official injury report and gameday designations for all 12 Sunday games.