An all-star offensive cast of Christian McCaffrey, Deebo Samuel and Brock Purdy all had contributions as their defense dominated en route to the 49ers defeating the Giants on Thursday night. 

San Francisco 49ers wide receiver Brandon Aiyuk is inactive for his team's Week 3 tilt against the New York Giants due to a shoulder injury. 

NFL.com's Eric Edholm breaks down four things to watch for when the New York Giants visit the San Francisco 49ers on Thursday night.

NFL.com keeps you up to date with all of the latest league news from around the NFL. Visit NFL.com's transaction hub for a daily breakdown.

NFL.com keeps you up to date with all of the latest league news from around the NFL. Visit NFL.com's transaction hub for a daily breakdown.

After a wild Week 1, Joel Smyth identifies eight notable nuggets to inform your fantasy decisions heading into Week 2. Do we trust Joe Burrow and Tee Higgins after opening week duds? Are the breakout rookie WRs for real?

Following standout performances Sunday, 49ers wideout Brandon Aiyuk and Dolphins quarterback Tua Tagovailoa were among the Players of the Week.

49ers wide receiver Brandon Aiyuk said on KNBR that QB Brock Purdy's swagger has become infectious. "He plays with an extreme poise, but also poise and urgency," Aiyuk said.

The 2023 NFL fantasy football season is here! Fantasy guru Adam Rank is here to help you prepare for your drafts by revealing his wide receiver rankings and tiers.

Sam Darnold kept it simple when explaining why he chose to sign with the San Francisco 49ers. "Guys are open, I mean, there's a lot of guys open on dang near every play," Darnold said. 

Will Brock Purdy win the 49ers' QB1 job? Can the defense help Kyle Shanahan and Co. get to the Super Bowl? Adam Rank examines the state of the San Francisco 49ers heading into the 2023 NFL season.

The deadline for NFL teams to option the fifth year on rookie contracts for their 2020 first-round picks is Tuesday, May 2.

San Francisco 49ers wide receiver Brandon Aiyuk doesn't see the Eagles being able to contain the Chiefs in Super Bowl LVII, predicting Kansas City will expose the Philadelphia defense. 

Philadelphia Eagles defensive coordinator Jonathan Gannon is well aware of the San Francisco 49ers' proclivity for getting yards after the catch, and he's emphasizing tackling ahead of the NFC Championship Game to prepare for it.

NFL.com's Kevin Patra breaks down five things to watch for when the Dallas Cowboys visit the San Francisco 49ers on Sunday in the NFC Divisional Round.

Marc Ross examines which first-round picks from the 2020 NFL Draft should have their fifth-year options picked up. Where do Dolphins QB Tua Tagovailoa and Packers QB Jordan Love stand?

49ers quarterback Brock Purdy saved his best statistical game for his most important test yet, overcoming shaky beginnings to go 18-of-30 passing for 332 yards and three TDs, plus another score on the ground in San Francisco's 41-23 win over the Seahawks.

NFL.com breaks down the best -- and worst -- fantasy matchups ahead of each week of the 2022 NFL fantasy football season.

Brock Purdy, the 2022 NFL Draft's "Mr. Irrelevant," couldn't be more relevant this week as the San Francisco 49ers look to extend their winning streak to six games, with their new QB1, when they host Tom Brady and the Buccaneers.

The 49ers came away from Sunday with a win over the Dolphins led by a dominant defense, but they lost Jimmy Garoppolo for the season. Jim Trotter examines the performance and what lies ahead for the team with rookie Brock Purdy in as the new QB1.

Marcas Grant breaks down some NFL fantasy football sleeper picks you should consider starting in Week 4 of the 2022 NFL season.

All the answers you're looking for about your lineup questions. Check out the latest in the Start 'Em, Sit 'Em for your 2022 NFL fantasy football league.

The 2022 NFL fantasy football season is just around the corner! Marcas Grant breaks down 12 players who are being drafted too low.

With 32 separate 53-man rosters across the NFL, it's easy for key contributors to fly under the radar. Today, Nick Shook spotlights one unsung hero from each NFC team.

NFL.com's Chase Goodbread breaks down four things to watch for when the San Francisco 49ers visit the Tennessee Titans in a TNF matchup full of playoff implications.

NFL Network's Ian Rapoport, Tom Pelissero and Mike Garafolo report on the injury status of San Francisco 49ers wide receivers Deebo Samuel and Brandon Aiyuk ahead of the Week 4 game vs. the Arizona Cardinals.

NFL Network's Michael Robinson goes to the film to break down how Brock Purdy looked off Pittsburgh Steelers defenders with his eyes before delivering an 8-yard touchdown strike to Brandon Aiyuk.

The "NFL Fantasy Live" crew discusses the players with rising stocks after Sunday of Week 1.

Watch every San Francisco 49ers wide receiver Brandon Aiyuk catch in 129-yard game vs. Pittsburgh Steelers during Week 1 of the 2023 NFL season.

San Francisco 49ers wide receiver Brandon Aiyuk comes back to football to snag quarterback Brock Purdy's 16-yard pass.

San Francisco 49ers wide receiver Brandon Aiyuk Mosses Pittsburgh Steelers cornerback Patrick Peterson for 19-yard TD reception to give 49ers 16-0 lead early in second quarter.

San Francisco 49ers wide receiver Brandon Aiyuk glides across middle for 23-yard catch and run to set up 49ers in great scoring position.

San Francisco 49ers quarterback Brock Purdy's first TD pass of '23 goes to wide-open wide receiver Brandon Aiyuk to give the 49ers 6-0 lead in the first quarter.

Watch all of the highlights from the Los Angeles Chargers and San Francisco 49ers in their Preseason Week 3 highlights

Watch all of the San Francisco 49ers' top plays from their game against the Los Angeles Chargers in Preseason Week 3 of the 2023 NFL season.

San Francisco 49ers wide receiver Brandon Aiyuk breaks free along the sideline for a 35-yard catch and run.

Marcas Grant, Michael F. Florio and Adam Rank talk about why they think the following wide receivers will have breakout fantasy football seasons in 2023: Chris Olave of the New Orleans Saints, Garrett Wilson of the New York Jets and Brandon Aiyuk of the San Francisco 49ers.

NFL Network's Jason McCourty shares his top 5 breakout wide receivers of 2023.

Did San Francisco 49ers wide receiver Brandon Aiyuk have a point in saying Kansas City Chiefs could "expose" Eagles defense?

Watch the 10 best highlight plays made by the San Francisco 49ers in the 2022 NFL season.

Watch San Francisco 49ers wide receiver Brandon Aiyuk's top plays from the 2022 season.

NFL Network's David Carr and Brian Baldinger explain why Cincinnati Bengals safety Jessie Bates III, Bengals offensive tackle Jackson Carman, Kansas City Chiefs wide receiver JuJu Smith-Schuster, Chiefs running back Jerick McKinnon, San Francisco 49ers wide receiver Brandon Aiyuk, 49ers linebacker Dre Greenlaw, Philadelphia Eagles offensive guard Isaac Seumalo and Eagles running back Kenneth Gainwell are some under-the-radar players to watch for on Championship Sunday in the 2022-23 NFL Playoffs.

San Francisco 49ers wide receiver Brandon Aiyuk looks like a route-running technician before making a 17-yard catch in the red zone.

San Francisco 49ers quarterback Brock Purdy goes way downtown to wide receiver Brandon Aiyuk for 31-yard gain.

San Francisco 49ers quarterback Brock Purdy lofts a 23-yard pass to wide receiver Brandon Aiyuk.

San Francisco 49ers quarterback Brock Purdy's first postseason pass pinpoints wide receiver Brandon Aiyuk for 19 yards.

Watch San Francisco 49ers quarterback Brock Purdy's five most improbable completions from the 2022 regular season, according to Next Gen Stats.

San Francisco 49ers quarterback Brock Purdy starts the second half with a 20-yard dime to wide receiver Brandon Aiyuk.

San Francisco 49ers wide receiver Brandon Aiyuk survives a hit to complete a 22-yard reception.

The "GMFB" crew shares which running back and wide receiver duo they believe will have the best Week 18 in fantasy.