Isaiah Simmons chases down Cam Newton for huge third-down sack

Some incredible endings top the list of the NFL's 5 awesome things from Week 6.

Watch the top plays of Week 6 during the NFL 2021 season.

Watch the best runs of Week 6 during the NFL 2021 season.

Watch all of Buffalo Bills quarterback Josh Allen's best plays from his 3-touchdown game in Week 6 of the 2021 season.

Watch all of the highlights from the Week 6 matchup between the Buffalo Bills and the Tennessee Titans.

Buffalo Bills wide receiver Isaiah McKenzie has a kick return touchdown called back because of a holding penalty.

Buffalo Bills quarterback Josh Allen's leap for a first down is stopped short.

Watch every Buffalo Bills wide receiver Stefon Diggs catch from 89-yard game during Week 6 of the NFL 2021 season.

The Tennessee Titans defense makes a game-winning stop against Buffalo Bills quarterback Josh Allen on fourth down.

Watch Tennessee Titans running back Derrick Henry's best plays from 3-TD game during Week 6 of the NFL 2021 season.

Buffalo Bills quarterback Josh Allen completes a pass for 20 yards to wide receiver Gabriel Davis.

Buffalo Bills quarterback Josh Allen throws a 31-yard pass to wide receiver Emmanuel Sanders.

Tennessee Titans running back Derrick Henry scores his third touchdown of the game on a 13-yard run.

Tennessee Titans defensive end Jeffery Simmons sacks Buffalo Bills quarterback Josh Allen for the Titans' third sack of the game.

Tennessee Titans quarterback Ryan Tannehill completes a pass on third down to wide receiver A.J. Brown.

Buffalo Bills tight end Dawson Knox throws a trick-play pass to quarterback Josh Allen for a two-point conversion.

Buffalo Bills tight end Tommy Sweeney receives his first career touchdown on a pass from quarterback Josh Allen.

The Tennessee Titans have a costly third-down pass interference call in the red zone.

Tennessee Titans running back Derrick Henry powers through the goal-line for his second touchdown of the game.

Tennessee Titans quarterback Ryan Tannehill completes a 14-yard pass to wide receiver A.J. Brown on fourth down.

Tennessee Titans running back Derrick Henry runs over Buffalo Bills safety Micah Hyde at the end of a run.

Buffalo Bills kicker Tyler Bass makes a 52-yard field goal that twists and turns inside the uprights.

Tennessee Titans head coach Mike Vrabel reacts to a touchdown pass from Buffalo Bills quarterback Josh Allen to wide receiver Cole Beasley.

Buffalo Bills quarterback Josh Allen throws a pass under pressure for 17 yards to wide receiver Stefon Diggs.

Tennessee Titans quarterback Ryan Tannehill scores a rushing touchdown.