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NFL Game Highlights

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Quick change! Colts fumble on the kick return to set up 49ers in prime scoring position

Indianapolis Colts running back Ameer Abdullah fumbles the ball on the kick return for a San Francisco 49ers fumble recovery.

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Kyle Shanahan on shifting goals to winning NFC West after clinching playoff berth with Lions loss in Week 16

San Francisco 49ers head coach Kyle Shanahan talks to the media after Week 16 win against the Indianapolis Colts about goals for the remainder of the 2025 NFL season.
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49ers vs. Colts highlights | Week 16

Highlights from the Week 16 matchup between the San Francisco 49ers and the Indianapolis Colts during the 2025 NFL season.
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Christian McCaffrey's best plays from 146-yard game vs. Colts | Week 16

Watch the best plays from San Francisco 49ers running back Christian McCaffrey's 146-yard game against the Indianapolis Colts in Week 16 of the 2025 NFL season.
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George Kittle's best plays from 115-yard game vs. Colts | Week 16

Watch the best plays from San Francisco 49ers tight end George Kittle's 115-yard game vs. the Indianapolis Colts in Week 16 of the 2025 NFL season.
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Philip Rivers' best throws from 277-yard, 2-TD game vs. 49ers | Week 16

Watch the best plays from Indianapolis Colts quarterback Philip Rivers' 277-yard, two-touchdown game against the San Francisco 49ers in Week 16 of the 2025 NFL season.
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Top catches | Week 16

Watch the top catches from Week 16 of the 2025 NFL season.
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Top plays | Week 16

Watch the top plays from Week 16 of the 2025 NFL season.
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Top defensive plays | Week 16

Watch the top defensive plays from Week 16 of the 2025 NFL season.
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Top touchdowns | Week 16

Watch the top touchdowns from Week 16 of the 2025 NFL season.
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Top runs | Week 16

Watch the top runs from Week 16 of the 2025 NFL season.
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Brock Purdy's best plays from 5-TD game vs. Colts | Week 16

Watch the best plays from San Francisco 49ers quarterback Brock Purdy's 5-touchdown game vs. the Indianapolis Colts in Week 16 of the 2025 NFL season.
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Rivers chucks a 33-yard pass to Alec Pierce entry into 49ers' territory

Indianapolis Colts quarterback Philip Rivers throws a deep 33-yard pass to wide receiver Alec Pierce.
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Can't-Miss Play: 74-yard TD! Dee Winters delivers pick-six score vs. Rivers on 'MNF'

San Francisco 49ers linebacker Dee Winters ices Indianapolis Colts with huge 74-yard pick-six against quarterback Philip Rivers.
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Bobbled INT! Bynum scoops up a crucial interception vs. Purdy

Indianapolis Colts cornerback Camryn Bynum takes advantage of the missed catch by San Francisco 49ers wide receiver Kendrick Bourne to secure an interception.
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Alfred Collins smacks the ball loose for a fumble and major loss of 15 yards

San Francisco 49ers defensive tackle Alfred Collins sacks Indianapolis Colts quarterback Philip Rivers, who fumbles the ball that is recovered by the Colts 5-yard line.
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Purdy's fifth TD of 'MNF' extends 49ers' lead to 40-27

San Francisco 49ers QB Brock Purdy notches his fifth TD of the night as he finds RB Christian McCaffrey for the score.
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Christian McCaffrey's 24-yard run vs. Colts marks RB's longest carry of 2025 season so far

San Francisco 49ers running back Christian McCaffery bolts out of the backfield for a 24-yard gain.
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Purdy dishes up a 17-yard pass to Jennings for a quick start to the drive

San Francisco 49ers quarterback Brock Purdy completes a 17-yard pass to wide receiver Jauan Jennings.
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Jonathan Taylor's 17th TD run of 2025 trims 49ers' lead to 34-26 in fourth quarter

Indianapolis Colts running back Jonathan Taylor sneaks into the end zone for a 1-yard touchdown.
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Philip Rivers lofts a 19-yard pass to Warren enroute to the sideline

Indianapolis Colts quarterback Philip Rivers completes a 19-yard pass to tight end Tyler Warren.
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Eddy Piñeiro's 38-yard FG boosts Niners lead to 34-20 vs. Colts

San Francisco 49ers kicker Eddy Piñeiro makes a 38-yard field goal.
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Jennings' jumper snags 19-yard pass from Brock Purdy

San Francisco 49ers wide receiver Jauan Jennings leaps to secure 19-yard pass from quarterback Brock Purdy.
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Blake Grupe drills a 51-yard FG vs. San Francisco

Indianapolis Colts kicker Blake Groupe makes a 51-yard field goal.
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Purdy's fourth TD pass of night hits Jennings, boosting 49ers' lead to 30-17

San Francisco 49ers quarterback Brock Purdy completes a 3-yard touchdown pass to wide receiver Jauan Jennings.
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Purdy drops a 15-yard dime into Kittle's bucket for red zone access

San Francisco 49ers quarterback Brock Purdy rolls out of the pocket to locate tight end George Kittle for a 15-yard gain.